Systemic autoimmune diseases co-existing with chronic hepatitis C virus infection (the HISPAMEC Registry): Patterns of clinical and immunological expression in 180 cases

Manuel Ramos-Casals, L. J. Jara, F. Medina, J. Rosas, J. Calvo-Alen, J. Mañá, J. M. Anaya, J. Font

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objectives. To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection. Methods. We analysed 180 patients diagnosed with SAD and chronic HCV infection seen consecutively at our centres during the last 10 years. The clinical and immunological patterns of disease expression were compared with 180 SAD-matched patients without chronic HCV infection. Results. A total of 180 HCV patients fulfilled the classification criteria for the following SAD: Sjögren's syndrome (n = 77), systemic lupus erythematosus (n = 43), rheumatoid arthritis (n = 14), antiphospholipid syndrome (n = 14), polyarteritis nodosa (n = 8) and other SAD (n = 24). One hundred and thirty (72%) patients were female and 50 (28%) male, with a mean age at SAD diagnosis of 50 years. The main immunologic features were antinuclear antibodies in 69% of patients, cryoglobulinaemia in 62%, hypocomplementaemia in 56% and rheumatoid factor (RF) in 56%, Compared with the SAD-matched HCV-negative group, SAD-HCV patients presented a lower prevalence of females (P = 0.016), an older age at SAD diagnosis (P = 0.039) and a higher prevalence of vasculitis (P <0.001) and neoplasia (P <0.001). Immunologically, SAD-HCV patients presented a lower prevalence of antinuclear (P = 0.036), anti-extractable nuclear antigen (P = 0.038) and anti-DNA (P = 0.005) antibodies, and a higher frequency of RF (P = 0.003), hypocomplementaemia (P <0.001) and cryoglobulins (P <0.001). Conclusions. In comparison with an SAD-matched HCV-negative population, SAD-HCV patients were older and more likely to be male, with a higher frequency of vasculitis, cryoglobulinaemia and neoplasia. This complex pattern of disease expression is generated by a chronic viral infection that induces both liver and autoimmune disease. © 2005 Blackwell Publishing Ltd.
Original languageEnglish (US)
Pages (from-to)549-557
Number of pages9
JournalJournal of Internal Medicine
DOIs
StatePublished - Jun 1 2005

Fingerprint

Chronic Hepatitis C
Virus Diseases
Hepacivirus
Autoimmune Diseases
Registries
Autoimmune Hepatitis
Cryoglobulinemia
Rheumatoid Factor
Vasculitis
Cryoglobulins
Polyarteritis Nodosa
Nuclear Antigens
Antiphospholipid Syndrome
Antinuclear Antibodies
Sjogren's Syndrome
Immune System Diseases
Systemic Lupus Erythematosus
Liver Diseases
Rheumatoid Arthritis
Neoplasms

Cite this

@article{cdd0719dff414fcf80ff1858b4d1d800,
title = "Systemic autoimmune diseases co-existing with chronic hepatitis C virus infection (the HISPAMEC Registry): Patterns of clinical and immunological expression in 180 cases",
abstract = "Objectives. To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection. Methods. We analysed 180 patients diagnosed with SAD and chronic HCV infection seen consecutively at our centres during the last 10 years. The clinical and immunological patterns of disease expression were compared with 180 SAD-matched patients without chronic HCV infection. Results. A total of 180 HCV patients fulfilled the classification criteria for the following SAD: Sj{\"o}gren's syndrome (n = 77), systemic lupus erythematosus (n = 43), rheumatoid arthritis (n = 14), antiphospholipid syndrome (n = 14), polyarteritis nodosa (n = 8) and other SAD (n = 24). One hundred and thirty (72{\%}) patients were female and 50 (28{\%}) male, with a mean age at SAD diagnosis of 50 years. The main immunologic features were antinuclear antibodies in 69{\%} of patients, cryoglobulinaemia in 62{\%}, hypocomplementaemia in 56{\%} and rheumatoid factor (RF) in 56{\%}, Compared with the SAD-matched HCV-negative group, SAD-HCV patients presented a lower prevalence of females (P = 0.016), an older age at SAD diagnosis (P = 0.039) and a higher prevalence of vasculitis (P <0.001) and neoplasia (P <0.001). Immunologically, SAD-HCV patients presented a lower prevalence of antinuclear (P = 0.036), anti-extractable nuclear antigen (P = 0.038) and anti-DNA (P = 0.005) antibodies, and a higher frequency of RF (P = 0.003), hypocomplementaemia (P <0.001) and cryoglobulins (P <0.001). Conclusions. In comparison with an SAD-matched HCV-negative population, SAD-HCV patients were older and more likely to be male, with a higher frequency of vasculitis, cryoglobulinaemia and neoplasia. This complex pattern of disease expression is generated by a chronic viral infection that induces both liver and autoimmune disease. {\circledC} 2005 Blackwell Publishing Ltd.",
author = "Manuel Ramos-Casals and Jara, {L. J.} and F. Medina and J. Rosas and J. Calvo-Alen and J. Ma{\~n}{\'a} and Anaya, {J. M.} and J. Font",
year = "2005",
month = "6",
day = "1",
doi = "10.1111/j.1365-2796.2005.01490.x",
language = "English (US)",
pages = "549--557",
journal = "Journal of Internal Medicine",
issn = "0954-6820",
publisher = "Wiley-Blackwell",

}

Systemic autoimmune diseases co-existing with chronic hepatitis C virus infection (the HISPAMEC Registry): Patterns of clinical and immunological expression in 180 cases. / Ramos-Casals, Manuel; Jara, L. J.; Medina, F.; Rosas, J.; Calvo-Alen, J.; Mañá, J.; Anaya, J. M.; Font, J.

In: Journal of Internal Medicine, 01.06.2005, p. 549-557.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Systemic autoimmune diseases co-existing with chronic hepatitis C virus infection (the HISPAMEC Registry): Patterns of clinical and immunological expression in 180 cases

AU - Ramos-Casals, Manuel

AU - Jara, L. J.

AU - Medina, F.

AU - Rosas, J.

AU - Calvo-Alen, J.

AU - Mañá, J.

AU - Anaya, J. M.

AU - Font, J.

PY - 2005/6/1

Y1 - 2005/6/1

N2 - Objectives. To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection. Methods. We analysed 180 patients diagnosed with SAD and chronic HCV infection seen consecutively at our centres during the last 10 years. The clinical and immunological patterns of disease expression were compared with 180 SAD-matched patients without chronic HCV infection. Results. A total of 180 HCV patients fulfilled the classification criteria for the following SAD: Sjögren's syndrome (n = 77), systemic lupus erythematosus (n = 43), rheumatoid arthritis (n = 14), antiphospholipid syndrome (n = 14), polyarteritis nodosa (n = 8) and other SAD (n = 24). One hundred and thirty (72%) patients were female and 50 (28%) male, with a mean age at SAD diagnosis of 50 years. The main immunologic features were antinuclear antibodies in 69% of patients, cryoglobulinaemia in 62%, hypocomplementaemia in 56% and rheumatoid factor (RF) in 56%, Compared with the SAD-matched HCV-negative group, SAD-HCV patients presented a lower prevalence of females (P = 0.016), an older age at SAD diagnosis (P = 0.039) and a higher prevalence of vasculitis (P <0.001) and neoplasia (P <0.001). Immunologically, SAD-HCV patients presented a lower prevalence of antinuclear (P = 0.036), anti-extractable nuclear antigen (P = 0.038) and anti-DNA (P = 0.005) antibodies, and a higher frequency of RF (P = 0.003), hypocomplementaemia (P <0.001) and cryoglobulins (P <0.001). Conclusions. In comparison with an SAD-matched HCV-negative population, SAD-HCV patients were older and more likely to be male, with a higher frequency of vasculitis, cryoglobulinaemia and neoplasia. This complex pattern of disease expression is generated by a chronic viral infection that induces both liver and autoimmune disease. © 2005 Blackwell Publishing Ltd.

AB - Objectives. To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection. Methods. We analysed 180 patients diagnosed with SAD and chronic HCV infection seen consecutively at our centres during the last 10 years. The clinical and immunological patterns of disease expression were compared with 180 SAD-matched patients without chronic HCV infection. Results. A total of 180 HCV patients fulfilled the classification criteria for the following SAD: Sjögren's syndrome (n = 77), systemic lupus erythematosus (n = 43), rheumatoid arthritis (n = 14), antiphospholipid syndrome (n = 14), polyarteritis nodosa (n = 8) and other SAD (n = 24). One hundred and thirty (72%) patients were female and 50 (28%) male, with a mean age at SAD diagnosis of 50 years. The main immunologic features were antinuclear antibodies in 69% of patients, cryoglobulinaemia in 62%, hypocomplementaemia in 56% and rheumatoid factor (RF) in 56%, Compared with the SAD-matched HCV-negative group, SAD-HCV patients presented a lower prevalence of females (P = 0.016), an older age at SAD diagnosis (P = 0.039) and a higher prevalence of vasculitis (P <0.001) and neoplasia (P <0.001). Immunologically, SAD-HCV patients presented a lower prevalence of antinuclear (P = 0.036), anti-extractable nuclear antigen (P = 0.038) and anti-DNA (P = 0.005) antibodies, and a higher frequency of RF (P = 0.003), hypocomplementaemia (P <0.001) and cryoglobulins (P <0.001). Conclusions. In comparison with an SAD-matched HCV-negative population, SAD-HCV patients were older and more likely to be male, with a higher frequency of vasculitis, cryoglobulinaemia and neoplasia. This complex pattern of disease expression is generated by a chronic viral infection that induces both liver and autoimmune disease. © 2005 Blackwell Publishing Ltd.

U2 - 10.1111/j.1365-2796.2005.01490.x

DO - 10.1111/j.1365-2796.2005.01490.x

M3 - Article

C2 - 15910559

SP - 549

EP - 557

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

SN - 0954-6820

ER -