Synthesis, crystal structure and hydrogen-bonding patterns in (RS)-1-carbamoyl pyrrolidine-2-carboxylic acid

Gerzon E. Delgado, Luis E. Seijas, Asiloé J. Mora, Teresa González, Alexander Briceño

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The title compound, N-carbamoyl-DL-proline, C 6H 10N 2O 3, crystallizes in the triclinic P-1 space group with unit cell parameters a = 7.610 (4) Å, b = 9.259 (5) Å, c = 11.749 (7) Å, α = 110.294 (11)°, β = 101.304 (13)°, γ = 91.391 (16)°, with two crystallographically independent molecules in the asymmetric unit. The ureido and carboxyl groups are equatorial and axial to the pyrrolidine rings, respectively. The pyrrolidine rings adopt envelope and twisted conformations in the residue A and B, respectively. The molecules are joined by N-H...O and O-H...O hydrogen bonds into cyclic structures with graph set R 2 2(8), forming infinite chains parallel to the cb plane with graph set C 2 2(14), that are further connected via N-H...O hydrogen bonds into a three-dimensional network.

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
JournalJournal of Chemical Crystallography
Volume42
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Condensed Matter Physics

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