Synthesis and Evaluation of the Potential Use of an Electro-Responsive Hydrogel for the Encapsulation of Carbon Dot-Curcumin Nanoplatforms

Nicolas J. Bonilla Fajardo, M. Natalia Ochoa Paipilla, Michelle D. Soto Florido, Sandra Ramirez-Clavijo, D. Fabio Mercado, Marcela Munera, Diana C. Rodriguez Burbano

Research output: Contribution to conferenceConference proceedingspeer-review

Abstract

Curcumin is a polyphenolic compound recently studied as a potential therapeutic agent for cancer treatment. However, this molecule possesses low solubility in water which complicates its direct use in the organism, making it essential to find a drug delivery system to carry this molecule through hydrophilic environments. To achieve this, carbon dots (CDs) with a polar surface were synthesized from citric acid and urea by solvothermal method, followed by the surface functionalization of the CDs via the adsorption of curcumin molecules (CD-Cur). This nanoplatform was encapsulated inside an electro-responsive hydrogel based on dextran and aniline (Dex/HDI/AT), which acts as a vehicle for CD-Cur. To evaluate the improvement of solubility of curcumin, a drug encapsulation test was carried out to compare its encapsulation rate to a molecule of great hydrophilicity, fluorescein. The results of FTIR, UV-Vis spectroscopy and zeta potential tests enabled to identify the composition of CDs and the functionalization of CD-Cur. The composition and structure of Dex/HDI/AT was confirmed by FTIR and SEM. Finally, the drug encapsulation test demonstrated the capacity of CDs to improve the interaction of hydrophobic curcumin molecules with aqueous-based environments such as the one offered by the DEX/HDI/AT hydrogel.

Original languageEnglish (US)
Pages405-415
Number of pages11
DOIs
StatePublished - 2024
Event9th Latin American Congress on Biomedical Engineering, CLAIB 2022 and 28th Brazilian Congress on Biomedical Engineering, CBEB 2022 - Florianópolis, Brazil
Duration: Oct 24 2022Oct 28 2022

Conference

Conference9th Latin American Congress on Biomedical Engineering, CLAIB 2022 and 28th Brazilian Congress on Biomedical Engineering, CBEB 2022
Country/TerritoryBrazil
CityFlorianópolis
Period10/24/2210/28/22

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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