Synthesis and Evaluation of the Potential Use of an Electro-Responsive Hydrogel for the Encapsulation of Carbon Dot-Curcumin Nanoplatforms

Nicolas J. Bonilla Fajardo, M. Natalia Ochoa Paipilla, Michelle D. Soto Florido, Sandra Ramirez-Clavijo, D. Fabio Mercado, Marcela Munera, Diana C. Rodriguez Burbano

Research output: Chapter in Book/ReportConference contribution

Abstract

Curcumin is a polyphenolic compound recently studied as a potential therapeutic agent for cancer treatment. However, this molecule possesses low solubility in water which complicates its direct use in the organism, making it essential to find a drug delivery system to carry this molecule through hydrophilic environments. To achieve this, carbon dots (CDs) with a polar surface were synthesized from citric acid and urea by solvothermal method, followed by the surface functionalization of the CDs via the adsorption of curcumin molecules (CD-Cur). This nanoplatform was encapsulated inside an electro-responsive hydrogel based on dextran and aniline (Dex/HDI/AT), which acts as a vehicle for CD-Cur. To evaluate the improvement of solubility of curcumin, a drug encapsulation test was carried out to compare its encapsulation rate to a molecule of great hydrophilicity, fluorescein. The results of FTIR, UV-Vis spectroscopy and zeta potential tests enabled to identify the composition of CDs and the functionalization of CD-Cur. The composition and structure of Dex/HDI/AT was confirmed by FTIR and SEM. Finally, the drug encapsulation test demonstrated the capacity of CDs to improve the interaction of hydrophobic curcumin molecules with aqueous-based environments such as the one offered by the DEX/HDI/AT hydrogel.

Original languageEnglish (US)
Title of host publication9th Latin American Congress on Biomedical Engineering and 28th Brazilian Congress on Biomedical Engineering - Proceedings of CLAIB and CBEB 2022—Volume 1
Subtitle of host publicationBioengineering and Biomaterials
EditorsJefferson Luiz Brum Marques, Cesar Ramos Rodrigues, Daniela Ota Hisayasu Suzuki, Renato García Ojeda, José Marino Neto
PublisherSpringer Science and Business Media Deutschland GmbH
Pages405-415
Number of pages11
ISBN (Print)9783031494000
DOIs
StatePublished - 2024
Event9th Latin American Congress on Biomedical Engineering, CLAIB 2022 and 28th Brazilian Congress on Biomedical Engineering, CBEB 2022 - Florianópolis, Brazil
Duration: Oct 24 2022Oct 28 2022

Publication series

NameIFMBE Proceedings
Volume98
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Conference

Conference9th Latin American Congress on Biomedical Engineering, CLAIB 2022 and 28th Brazilian Congress on Biomedical Engineering, CBEB 2022
Country/TerritoryBrazil
CityFlorianópolis
Period10/24/2210/28/22

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

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