STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians

R. J. Palomino-Morales; A. Rojas-Villarraga; C. I. González; G. Ramírez; J. M. Anaya; J. Martín

doi:10.1038/gene.2008.30

STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians

R. J. Palomino-Morales, A. Rojas-Villarraga, C. I. González, G. Ramírez, J. M. Anaya, J. Martín

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Abstract

The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.

Original language	English (US)
Pages (from-to)	379-382
Number of pages	4
Journal	Genes and Immunity
Volume	9
Issue number	4
DOIs	https://doi.org/10.1038/gene.2008.30
State	Published - Jun 2008

All Science Journal Classification (ASJC) codes

Immunology
Genetics
Genetics(clinical)

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10.1038/gene.2008.30

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title = "STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians",

abstract = "The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.",

author = "Palomino-Morales, {R. J.} and A. Rojas-Villarraga and Gonz{\'a}lez, {C. I.} and G. Ram{\'i}rez and Anaya, {J. M.} and J. Mart{\'i}n",

note = "Funding Information: We thank all the participants in this study. This work was supported by grant SAF2006-00398 from Plan Nacional de I + D + I (Spain), by the Junta de Andaluc{\'i}a, grupo CTS-180 (Spain), the Rosario University (Colombia) and Colciencias, Colombia (grant 1102-04-12905). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2008",

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AU - Palomino-Morales, R. J.

AU - Rojas-Villarraga, A.

AU - González, C. I.

AU - Ramírez, G.

AU - Anaya, J. M.

AU - Martín, J.

N1 - Funding Information: We thank all the participants in this study. This work was supported by grant SAF2006-00398 from Plan Nacional de I + D + I (Spain), by the Junta de Andalucía, grupo CTS-180 (Spain), the Rosario University (Colombia) and Colciencias, Colombia (grant 1102-04-12905). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2008/6

Y1 - 2008/6

N2 - The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.

AB - The aim of this study was to determine the influence of STAT4 (rs7574865) and TRAF1/C5 (rs10818488 and rs2900180) gene polymorphisms on the risk of developing rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) in a Colombian population. This was a case-control study in which 839 individuals with RA (N = 274) and SLE (N = 144) and matched healthy controls (N = 421) were included. Genotyping was performed by using a polymerase chain reaction system with pre-developed TaqMan allelic discrimination assay. STAT4 rs7574865T allele disclosed a significant influence on the risk of developing SLE (P = 0.0005; OR 1.62, 95% CI 1.22-2.16) and RA (P = 0.008; OR 1.36; 95% CI 1.08-1.71), whereas no effect on these autoimmune diseases was observed for the TRAF1/C5 polymorphisms examined. Our data strengthen STAT4 rs7574865 polymorphism as a susceptibility factor for RA and SLE and provide further evidence for a common origin of autoimmune diseases.

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STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians

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