Standard deviations and correlations of GC levels in DNA sequences

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In a DNA sequence that exhibits long-range correlations, standard deviations among the GC levels of its segments can be up to an order of magnitude higher than in a sequence consisting of independent, identically distributed nucleotides. Conversely, plots of inter-segment standard deviations vs. segment length reveal quantitative information about the correlations present in a sequence. We present and discuss formulae that relate long-range (power-law) correlations between the nucleotides of a sequence to the expected standard deviations of the GC levels of its segments, and to the correlations between them.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
Issue number1-2
StatePublished - Oct 3 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics


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