Sporozoite and liver stage antigen Plasmodium falciparum peptides bind specifically to human hepatocytes

Adriana Janneth Bermudez Quintero, Alvaro Puentes, Javier García, Ricardo Vera, Ramses Lopez, Jorge Suarez, Hernando Curtidor, Marisol Ocampo Cifuentes, Diana R. Tovar, Martha Forero, Jimena Cortés, Mauricio Urquiza, Manuel Elkin Patarroyo

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 ( 21IWASEKKDEKEASEQGEESHY40) and 20611 ( 64KKDDGTDKVQEKVLEKSPKY83) peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSSMKMDEKMAAMQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides' (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes
Original languageEnglish (US)
Pages (from-to)1150-1156
Number of pages7
JournalVaccine
Volume22
Issue number9-10
DOIs
StatePublished - Mar 12 2004

Fingerprint Dive into the research topics of 'Sporozoite and liver stage antigen Plasmodium falciparum peptides bind specifically to human hepatocytes'. Together they form a unique fingerprint.

Cite this