Abstract
The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.
Original language | English (US) |
---|---|
Article number | 106 |
Journal | Frontiers in Chemistry |
Volume | 6 |
Issue number | APR |
DOIs | |
State | Published - Apr 1 2018 |
All Science Journal Classification (ASJC) codes
- Chemistry(all)