Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components

Adriana Bermudez; Martha P. Alba; Magnolia Vanegas; Manuel A. Patarroyo; Manuel E. Patarroyo

doi:10.3389/fchem.2018.00106

Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components

Adriana Bermudez, Martha P. Alba, Magnolia Vanegas, Manuel A. Patarroyo, Manuel E. Patarroyo

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

Original language	English (US)
Article number	106
Journal	Frontiers in Chemistry
Volume	6
Issue number	APR
DOIs	https://doi.org/10.3389/fchem.2018.00106
State	Published - Apr 1 2018

All Science Journal Classification (ASJC) codes

Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fchem.2018.00106

Cite this

@article{d9713bb15ca6472fbbd84beb90a48f70,

title = "Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components",

abstract = "The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.",

author = "Adriana Bermudez and Alba, {Martha P.} and Magnolia Vanegas and Patarroyo, {Manuel A.} and Patarroyo, {Manuel E.}",

year = "2018",

month = apr,

day = "1",

doi = "10.3389/fchem.2018.00106",

language = "English (US)",

volume = "6",

journal = "Frontiers in Chemistry",

issn = "2296-2646",

publisher = "Frontiers Media S. A.",

number = "APR",

}

TY - JOUR

T1 - Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components

AU - Bermudez, Adriana

AU - Alba, Martha P.

AU - Vanegas, Magnolia

AU - Patarroyo, Manuel A.

AU - Patarroyo, Manuel E.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

AB - The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

UR - http://www.scopus.com/inward/record.url?scp=85047461182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047461182&partnerID=8YFLogxK

U2 - 10.3389/fchem.2018.00106

DO - 10.3389/fchem.2018.00106

M3 - Article

AN - SCOPUS:85047461182

SN - 2296-2646

VL - 6

JO - Frontiers in Chemistry

JF - Frontiers in Chemistry

IS - APR

M1 - 106

ER -