Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components

Adriana Bermudez, Martha P Alba, Magnolia Vanegas, Manuel A Patarroyo, Manuel E Patarroyo

Research output: Contribution to journalArticle

Abstract

The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalFrontiers in Chemistry
Volume6
Issue number106
DOIs
StatePublished - Apr 6 2018

Cite this

Bermudez, Adriana ; Alba, Martha P ; Vanegas, Magnolia ; Patarroyo, Manuel A ; Patarroyo, Manuel E. / Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components. In: Frontiers in Chemistry. 2018 ; Vol. 6, No. 106. pp. 1-10.
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Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components. / Bermudez, Adriana; Alba, Martha P; Vanegas, Magnolia; Patarroyo, Manuel A; Patarroyo, Manuel E.

In: Frontiers in Chemistry, Vol. 6, No. 106, 06.04.2018, p. 1-10.

Research output: Contribution to journalArticle

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