Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components

Adriana Bermudez, Martha P. Alba, Magnolia Vanegas, Manuel A. Patarroyo, Manuel E. Patarroyo

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity.

Original languageEnglish (US)
Article number106
JournalFrontiers in Chemistry
Volume6
Issue numberAPR
DOIs
StatePublished - Apr 1 2018

All Science Journal Classification (ASJC) codes

  • General Chemistry

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