Sjögren's syndrome at the crossroad of polyautoimmunity

Manuel J. Amador-Patarroyo, Juan Guillermo Arbelaez, Ruben D. Mantilla, Alberto Rodriguez-Rodriguez, Jorge Cárdenas-Roldán, Ricardo Pineda-Tamayo, Mayra R. Guarin, Liliana Lopez Kleine, Adriana Rojas-Villarraga, Juan Manuel Anaya

Research output: Contribution to journalResearch Articlepeer-review

75 Scopus citations


The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalJournal of Autoimmunity
Issue number3
StatePublished - Sep 2012

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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