TY - JOUR
T1 - Shared HLA class II in six autoimmune diseases in Latin America
T2 - A meta-analysis
AU - Cruz-Tapias, Paola
AU - Pérez-Fernández, Oscar M.
AU - Rojas-Villarraga, Adriana
AU - Rodríguez-Rodríguez, Alberto
AU - Arango, María Teresa
AU - Anaya, Juan Manuel
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95CI: 1.4111.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.
AB - The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95CI: 1.4111.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.
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U2 - 10.1155/2012/569728
DO - 10.1155/2012/569728
M3 - Review article
AN - SCOPUS:84871305628
SN - 2090-0422
VL - 1
JO - Autoimmune Diseases
JF - Autoimmune Diseases
IS - 1
M1 - 569728
ER -