Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis

Paola Cruz-Tapias, Oscar M. Pérez-Fernández, Adriana Rojas-Villarraga, Alberto Rodríguez-Rodríguez, María Teresa Arango, Juan Manuel Anaya

Research output: Contribution to journalLiterature review

26 Citations (Scopus)

Abstract

The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95CI: 1.4111.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics. © 2012 Paola Cruz-Tapias et al.
Original languageEnglish (US)
JournalAutoimmune Diseases
DOIs
StatePublished - May 21 2012

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Latin America
HLA Antigens
Type 1 Diabetes Mellitus
Autoimmune Diseases
Meta-Analysis
Alleles
Autoimmune Hepatitis
Multiple Sclerosis
Rheumatoid Arthritis
Sjogren's Syndrome
Genetic Predisposition to Disease
Systemic Lupus Erythematosus
Autoantibodies
Genes

Cite this

Cruz-Tapias, P., Pérez-Fernández, O. M., Rojas-Villarraga, A., Rodríguez-Rodríguez, A., Arango, M. T., & Anaya, J. M. (2012). Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. Autoimmune Diseases. https://doi.org/10.1155/2012/569728
Cruz-Tapias, Paola ; Pérez-Fernández, Oscar M. ; Rojas-Villarraga, Adriana ; Rodríguez-Rodríguez, Alberto ; Arango, María Teresa ; Anaya, Juan Manuel. / Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. In: Autoimmune Diseases. 2012.
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abstract = "The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95CI: 1.4111.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sj{\"o}gren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics. {\circledC} 2012 Paola Cruz-Tapias et al.",
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Cruz-Tapias, P, Pérez-Fernández, OM, Rojas-Villarraga, A, Rodríguez-Rodríguez, A, Arango, MT & Anaya, JM 2012, 'Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis', Autoimmune Diseases. https://doi.org/10.1155/2012/569728

Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. / Cruz-Tapias, Paola; Pérez-Fernández, Oscar M.; Rojas-Villarraga, Adriana; Rodríguez-Rodríguez, Alberto; Arango, María Teresa; Anaya, Juan Manuel.

In: Autoimmune Diseases, 21.05.2012.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis

AU - Cruz-Tapias, Paola

AU - Pérez-Fernández, Oscar M.

AU - Rojas-Villarraga, Adriana

AU - Rodríguez-Rodríguez, Alberto

AU - Arango, María Teresa

AU - Anaya, Juan Manuel

PY - 2012/5/21

Y1 - 2012/5/21

N2 - The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95CI: 1.4111.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics. © 2012 Paola Cruz-Tapias et al.

AB - The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95CI: 1.4111.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics. © 2012 Paola Cruz-Tapias et al.

U2 - 10.1155/2012/569728

DO - 10.1155/2012/569728

M3 - Literature review

C2 - 22577522

JO - Autoimmune Diseases

JF - Autoimmune Diseases

SN - 2090-0422

ER -

Cruz-Tapias P, Pérez-Fernández OM, Rojas-Villarraga A, Rodríguez-Rodríguez A, Arango MT, Anaya JM. Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. Autoimmune Diseases. 2012 May 21. https://doi.org/10.1155/2012/569728