Serum levels of secretory IgA and in vitro production of IgA in rheumatoid arthritis

C. Jorgensen, C. Bologna, M. Gutierrez, J. M. Anaya, T. Reme, J. Sany

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6 Scopus citations

Abstract

Twenty-three percent of rheumatoid arthritis (RA) patients show an increase of serum IgA concentrations. To determine the role of mucous- associated lymphoid tissue (MALT) in the elevation of serum IgA in RA, we studied the serum secretory-IgA (s-IgA) in 63 RA patients and in 30 healthy controls. We also analysed the secretion of circulating B cells producing IgA, which is known to reflect mucous tissue activity, in a subgroup of 15 patients with increased serum IgA concentrations, and in control patients. The mean s-IgA in the RA patients was 0.046 mg/ml ± 0.064, versus 0.002 ± 0.004 mg/ml in controls (not significant). Active disease defined by clinical criteria was associated with an increase in serum s-IgA (p < 0.001). Furthermore, in a subgroup of RA patients with high serum IgA levels, we found an increase in in vitro IgA production by circulating blood lymphocytes (17.39 ± 15.2 μg/ml), versus RA patients with normal serum IgA levels or controls (p < 0.001). These results were not modified by LPS or PWM. Our results further support the hypothesis of primary MALT activation following environmental antigenic stimulation in RA patients.

Original languageEnglish (US)
Pages (from-to)541-544
Number of pages4
JournalClinical and Experimental Rheumatology
Volume11
Issue number5
StatePublished - 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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