Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America

Stéphane Morisset; François Peyron; Jean R. Lobry; Justus Garweg; Josette Ferrandiz; Karine Musset; Jorge Enrique Gomez-Marin; Alejandra de la Torre; Magali Demar; Bernard Carme; Corinne Mercier; Jean François Garin; Marie France Cesbron-Delauw

doi:10.1016/j.micinf.2008.04.001

Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America

Stéphane Morisset, François Peyron, Jean R. Lobry, Justus Garweg, Josette Ferrandiz, Karine Musset, Jorge Enrique Gomez-Marin, Alejandra de la Torre, Magali Demar, Bernard Carme, Corinne Mercier, Jean François Garin, Marie France Cesbron-Delauw

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Field isolates of Toxoplasma gondii in Europe and North America have been grouped into three clonal lineages that display different virulence in mice. Whether the genetic structure of the parasite is related to clinical expression in humans has not yet been demonstrated. We developed an enzyme-linked immunosorbent assay which uses lineage-specific, polymorphic polypeptides derived from the dense granule antigens, GRA5 and GRA6. Our goal was to compare serotypical patterns observed in asymptomatic versus symptomatic (ocular disease and severe infection in human immunodeficiency virus (HIV)-positive patients) infections among patients from Europe and South America. Independent of the clinical presentation of the disease, serotypes differed according to geographical origin, with a homogeneous distribution of serotype II in Europe and of serotypes I and III in South America. We conclude that GRA5-GRA6 serotyping is an interesting tool to study serotype prevalence in populations but it is not an accurate marker of pathogenicity of Toxoplasma infection in humans.

Translated title of the contribution	Serotipado de Toxoplasma gondii: sorprendente patrón homogéneo entre las infecciones sintomáticas y asintomáticas en Europa y América del Sur
Original language	English (US)
Pages (from-to)	742-747
Number of pages	6
Journal	Microbes and Infection
DOIs	https://doi.org/10.1016/j.micinf.2008.04.001
State	Published - Jun 1 2008
Externally published	Yes

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Morisset, S., Peyron, F., Lobry, J. R., Garweg, J., Ferrandiz, J., Musset, K., Gomez-Marin, J. E., de la Torre, A., Demar, M., Carme, B., Mercier, C., Garin, J. F., & Cesbron-Delauw, M. F. (2008). Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America. Microbes and Infection, 742-747. https://doi.org/10.1016/j.micinf.2008.04.001

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title = "Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America",

abstract = "Field isolates of Toxoplasma gondii in Europe and North America have been grouped into three clonal lineages that display different virulence in mice. Whether the genetic structure of the parasite is related to clinical expression in humans has not yet been demonstrated. We developed an enzyme-linked immunosorbent assay which uses lineage-specific, polymorphic polypeptides derived from the dense granule antigens, GRA5 and GRA6. Our goal was to compare serotypical patterns observed in asymptomatic versus symptomatic (ocular disease and severe infection in human immunodeficiency virus (HIV)-positive patients) infections among patients from Europe and South America. Independent of the clinical presentation of the disease, serotypes differed according to geographical origin, with a homogeneous distribution of serotype II in Europe and of serotypes I and III in South America. We conclude that GRA5-GRA6 serotyping is an interesting tool to study serotype prevalence in populations but it is not an accurate marker of pathogenicity of Toxoplasma infection in humans. ",

author = "St{\'e}phane Morisset and Fran{\c c}ois Peyron and Lobry, {Jean R.} and Justus Garweg and Josette Ferrandiz and Karine Musset and Gomez-Marin, {Jorge Enrique} and {de la Torre}, Alejandra and Magali Demar and Bernard Carme and Corinne Mercier and Garin, {Jean Fran{\c c}ois} and Cesbron-Delauw, {Marie France}",

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doi = "10.1016/j.micinf.2008.04.001",

language = "English (US)",

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Morisset, S, Peyron, F, Lobry, JR, Garweg, J, Ferrandiz, J, Musset, K, Gomez-Marin, JE, de la Torre, A, Demar, M, Carme, B, Mercier, C, Garin, JF & Cesbron-Delauw, MF 2008, 'Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America', Microbes and Infection, pp. 742-747. https://doi.org/10.1016/j.micinf.2008.04.001

TY - JOUR

T1 - Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America

AU - Morisset, Stéphane

AU - Peyron, François

AU - Lobry, Jean R.

AU - Garweg, Justus

AU - Ferrandiz, Josette

AU - Musset, Karine

AU - Gomez-Marin, Jorge Enrique

AU - de la Torre, Alejandra

AU - Demar, Magali

AU - Carme, Bernard

AU - Mercier, Corinne

AU - Garin, Jean François

AU - Cesbron-Delauw, Marie France

PY - 2008/6/1

Y1 - 2008/6/1

N2 - Field isolates of Toxoplasma gondii in Europe and North America have been grouped into three clonal lineages that display different virulence in mice. Whether the genetic structure of the parasite is related to clinical expression in humans has not yet been demonstrated. We developed an enzyme-linked immunosorbent assay which uses lineage-specific, polymorphic polypeptides derived from the dense granule antigens, GRA5 and GRA6. Our goal was to compare serotypical patterns observed in asymptomatic versus symptomatic (ocular disease and severe infection in human immunodeficiency virus (HIV)-positive patients) infections among patients from Europe and South America. Independent of the clinical presentation of the disease, serotypes differed according to geographical origin, with a homogeneous distribution of serotype II in Europe and of serotypes I and III in South America. We conclude that GRA5-GRA6 serotyping is an interesting tool to study serotype prevalence in populations but it is not an accurate marker of pathogenicity of Toxoplasma infection in humans.

AB - Field isolates of Toxoplasma gondii in Europe and North America have been grouped into three clonal lineages that display different virulence in mice. Whether the genetic structure of the parasite is related to clinical expression in humans has not yet been demonstrated. We developed an enzyme-linked immunosorbent assay which uses lineage-specific, polymorphic polypeptides derived from the dense granule antigens, GRA5 and GRA6. Our goal was to compare serotypical patterns observed in asymptomatic versus symptomatic (ocular disease and severe infection in human immunodeficiency virus (HIV)-positive patients) infections among patients from Europe and South America. Independent of the clinical presentation of the disease, serotypes differed according to geographical origin, with a homogeneous distribution of serotype II in Europe and of serotypes I and III in South America. We conclude that GRA5-GRA6 serotyping is an interesting tool to study serotype prevalence in populations but it is not an accurate marker of pathogenicity of Toxoplasma infection in humans.

U2 - 10.1016/j.micinf.2008.04.001

DO - 10.1016/j.micinf.2008.04.001

M3 - Article

SN - 1286-4579

SP - 742

EP - 747

JO - Microbes and Infection

JF - Microbes and Infection

ER -

Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America

Abstract

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