Secondary psychosis induced by metabolic disorders

Olivier Bonnot, Paula Herrera, Sylvie Tordjman, Mark Walterfang

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Metabolic disorders are not well recognized by psychiatrists as a possible source of secondary psychoses. Inborn errors of metabolism (IEMs) are not frequent. Although their prompt diagnosis may lead to suitable treatments. IEMs are well known to paediatricians, in particular for their most serious forms, having an early expression most of the time. Recent years discoveries have unveiled later expression forms, and sometimes very discreet first physical signs. There is a growing body of evidence that supports the hypothesis that IEMs can manifest as atypical psychiatric symptoms, even in the absence of clear neurological symptoms. In the present review, we propose a detailed overview at schizophrenia-like and autism-like symptoms that can lead practitioners to bear in mind an IEM. Other psychiatric manifestations are also found, as behavioral, cognitive, learning and mood disorders. However, they are less frequent. Ensuring an accurate IEM diagnosis, in front of these psychiatric symptoms should be a priority, in order to grant suitable and valuable treatment for these pathologies.

Original languageEnglish (US)
Article number177
JournalFrontiers in Neuroscience
Volume9
Issue numberAPR
DOIs
StatePublished - May 19 2015

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Author Keywords

  • Concept

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