Screening for mutations of the FOXO4 gene in premature ovarian failure patients

Dora Janeth Fonseca, Eliana Garzón, Besma Lakhal, Rim Braham, Diego Ojeda, Hatem Elghezal, Ali Saâd, Carlos Martín Restrepo, Paul Laissue

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)339-341
Number of pages3
JournalReproductive BioMedicine Online
DOIs
StatePublished - Mar 1 2012

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