Role of vasoactive substances in the segmentary vasomotor response following spinal cord stimulation an experimental study

M. J. Sánchez-Ledesma, G. García-March, J. Gonçalves, J. Anaya, I. Silva, J. M. Gonzalez-Buitrago, J. A. Navajo, J. Broseta

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

It is presumed today that spinal cord stimulation induces local delivery of vasoactive substances, such as prostacyclins, histamine, substance P, and vasoactive neuropeptides, in the perivascular environment and the vascular wall to mediate the segmental vasodilator response. To investigate this mechanism, 9 dogs were subjected to low thoracic spinal cord stimulation. Venous and arterial blood samples from the pares- thesic area in the lower limbs were obtained before and 120 min after stimulation to measure changes in the plasma concentration of vasoactive intestinal peptide, substance P, and histamine. The results were compared with those obtained from vessels of the upper limbs. Blood flow changes following stimulation were recorded by electromagnetic flowmeters. Local arterial vasoactive intestinal peptide showed a mean increase of 33% after 60 min of stimulation. Changes concerning substance P were inconclusive. Local arterial and venous histamine concentrations increased 26 and 29%, respectively, after 60 min of stimulation.

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalStereotactic and Functional Neurosurgery
Volume54
Issue number1-8
DOIs
StatePublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Role of vasoactive substances in the segmentary vasomotor response following spinal cord stimulation an experimental study'. Together they form a unique fingerprint.

Cite this