Resistance and overcoming resistance in breast cancer

Andrea Luque-Bolivar, Erika Pérez-Mora, Victoria Eugenia Villegas, Milena Rondón-Lagos

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is the main cause of cancer-related death in women worldwide. One of the most significant clinical problems in the treatment of patients with BC is the development of therapeutic resistance. Therefore, elucidating the molecular mechanisms involved in drug resistance is critical. The therapeutic decision for the management of patients with BC is based not only on the assessment of prognostic factors but also on the evaluation of clinical and pathological parameters. Although this has been a successful approach, some patients relapse and/or eventually develop resistance to treatment. This review is focused on recent studies on the possible biological and molecular mechanisms involved in both response and resistance to treatment in BC. Additionally, emerging treatments that seek to overcome resistance and reduce side effects are also described. A greater understanding of the mechanisms of action of treatments used in BC might contribute not only to the enhancement of our understanding of the mechanisms involved in the development of resistance but also to the optimization of the existing treatment regimens.

Translated title of the contributionResistencia y superación de la resistencia en cáncer de mama.
Original languageEnglish (US)
Pages (from-to)211-229
Number of pages19
JournalBreast Cancer: Targets and Therapy
Volume12
DOIs
StatePublished - Nov 11 2020

All Science Journal Classification (ASJC) codes

  • Oncology

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