TY - JOUR
T1 - Resistance and overcoming resistance in breast cancer
AU - Luque-Bolivar, Andrea
AU - Pérez-Mora, Erika
AU - Villegas, Victoria Eugenia
AU - Rondón-Lagos, Milena
N1 - Publisher Copyright:
© 2020 Luque-Bolivar et al.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/11
Y1 - 2020/11/11
N2 - The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is the main cause of cancer-related death in women worldwide. One of the most significant clinical problems in the treatment of patients with BC is the development of therapeutic resistance. Therefore, elucidating the molecular mechanisms involved in drug resistance is critical. The therapeutic decision for the management of patients with BC is based not only on the assessment of prognostic factors but also on the evaluation of clinical and pathological parameters. Although this has been a successful approach, some patients relapse and/or eventually develop resistance to treatment. This review is focused on recent studies on the possible biological and molecular mechanisms involved in both response and resistance to treatment in BC. Additionally, emerging treatments that seek to overcome resistance and reduce side effects are also described. A greater understanding of the mechanisms of action of treatments used in BC might contribute not only to the enhancement of our understanding of the mechanisms involved in the development of resistance but also to the optimization of the existing treatment regimens.
AB - The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is the main cause of cancer-related death in women worldwide. One of the most significant clinical problems in the treatment of patients with BC is the development of therapeutic resistance. Therefore, elucidating the molecular mechanisms involved in drug resistance is critical. The therapeutic decision for the management of patients with BC is based not only on the assessment of prognostic factors but also on the evaluation of clinical and pathological parameters. Although this has been a successful approach, some patients relapse and/or eventually develop resistance to treatment. This review is focused on recent studies on the possible biological and molecular mechanisms involved in both response and resistance to treatment in BC. Additionally, emerging treatments that seek to overcome resistance and reduce side effects are also described. A greater understanding of the mechanisms of action of treatments used in BC might contribute not only to the enhancement of our understanding of the mechanisms involved in the development of resistance but also to the optimization of the existing treatment regimens.
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U2 - 10.2147/BCTT.S270799
DO - 10.2147/BCTT.S270799
M3 - Research Article
C2 - 33204149
AN - SCOPUS:85098162828
SN - 1179-1314
VL - 12
SP - 211
EP - 229
JO - Breast Cancer: Targets and Therapy
JF - Breast Cancer: Targets and Therapy
ER -