Replication of alphaviruses in cultures of donkey monocytes

Research output: Contribution to JournalResearch Articlepeer-review

Abstract

Representative strains of Venezuelan equine encephalitis virus (VEEV) and Eastern equine encephalitis virus (EEEV) were compared for their ability to grow in cultures of unstimulated leucocytes and monocytes derived from donkey peripheral blood. Replication of epizootic and vaccine strains of VEEV, but not of enzootic strains was observed in this system. Only a minority of monocytes supported virus replication as detected by immunofluorescence, electron microscopy and infectious center assays. EEEV did not appear to replicate in this cell system although virus attached to and was internalized by monocytes.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalArchives of Virology
Volume87
Issue number3-4
DOIs
StatePublished - Sep 1986
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

  • Virology

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