Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: A next-generation sequencing study

Z. Hawi, T.D.R. Cummins, J. Tong, M. Arcos-Burgos, Q. Zhao, N. Matthews, D.P. Newman, B. Johnson, A. Vance, H.S. Heussler, F. Levy, S. Easteal, N.R. Wray, E. Kenny, D. Morris, L. Kent, M. Gill, M.A. Bellgrove

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here we believe we performed the first large-scale next-generation targeted sequencing study of ADHD in 152 child and adolescent cases and 188 controls across an a priori set of 117 genes. A multi-marker gene-level analysis of rare (
Original languageEnglish (US)
Pages (from-to)580-584
Number of pages5
JournalMolecular Psychiatry
Volume22
Issue number4
DOIs
StatePublished - 2017

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