Prevalence of classic and non-classic antiphospholipid antibodies in multiple sclerosis

Dana Ben Ami Shor, Guy A. Weiss, Ori Barzilai, Maya Ram, Juan Manuel Anaya, Yehuda Shoenfeld, Yaniv Sherer

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings. Objectives: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS. Methods: Using the BioPlex™ 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls. Results: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine- β2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups. Conclusions: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain.

Original languageEnglish (US)
Pages (from-to)559-562
Number of pages4
JournalIsrael Medical Association Journal
Volume17
Issue number9
StatePublished - Sep 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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