TY - JOUR
T1 - Prevalence of celiac disease in Latin America
T2 - A systematic review and meta-regression
AU - Parra-Medina, Rafael
AU - Molano-Gonzalez, Nicolás
AU - Rojas-Villarraga, Adriana
AU - Agmon-Levin, Nancy
AU - Arango, Maria Teresa
AU - Shoenfeld, Yehuda
AU - Anaya, Juan Manuel
N1 - Publisher Copyright:
© 2015 Parra-Medina et al.
PY - 2015/5/5
Y1 - 2015/5/5
N2 - Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis. Methods and Findings: This was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46%and 0.64%. The prevalence of CD in firstdegree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies). Conclusions: Although CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.
AB - Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in susceptible individuals, and its prevalence varies depending on the studied population. Given that information on CD in Latin America is scarce, we aimed to investigate the prevalence of CD in this region of the world through a systematic review and meta-analysis. Methods and Findings: This was a two-phase study. First, a cross-sectional analysis from 981 individuals of the Colombian population was made. Second, a systematic review and meta-regression analysis were performed following the Preferred Reporting Items for Systematic Meta- Analyses (PRISMA) guidelines. Our results disclosed a lack of celiac autoimmunity in the studied Colombian population (i.e., anti-tissue transglutaminase (tTG) and IgA anti-endomysium (EMA)). In the systematic review, 72 studies were considered. The estimated prevalence of CD in Latin Americans ranged between 0.46%and 0.64%. The prevalence of CD in firstdegree relatives of CD probands was 5.5%. The coexistence of CD and type 1 diabetes mellitus varied from 4.6% to 8.7%, depending on the diagnosis methods (i.e., autoantibodies and/or biopsies). Conclusions: Although CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.
UR - http://www.scopus.com/inward/record.url?scp=84929347267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929347267&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0124040
DO - 10.1371/journal.pone.0124040
M3 - Review article
C2 - 25942408
AN - SCOPUS:84929347267
SN - 1932-6203
VL - 10
JO - PLOS ONE
JF - PLOS ONE
IS - 5
M1 - e0124040
ER -
