Usos terapéuticos potenciales de los antagonistas opioides: Fisiopatología y evidencia preclínica

Translated title of the contribution: Potential therapeutic uses of opioid antagonists: Pathophysiology and preclinical evidence

Mauricio O Nava-Mesa, Angelica Tellez-Arevalo, Daniel Rojas-Kozhakin, Carlos A Calderon-Ospina

Research output: Contribution to journalArticlepeer-review

Abstract

Opioid system, which involved endogenous opioid peptides and their receptors (Miu, Kappa, delta and ORL), has a main role in the physiology of several systems. At the same time, there is cumulating evidence in the role of the opioid system in the physiopathology of several disorders in the central nervous, endocrine and immunological system. The modulation of the opioid system using nonspecific antagonists may have a therapeutic role in the symptomatic management of several diseases, as well as, in the emergency management of opioid analgesic overdose, opioid dependence and to reduce the drug side effects of the opioid agonists used in chronic pain. This paper aims to review the pharmacology of specific and nonspecific opioid antagonists, and update on possible new indications and therapeutic uses of such antagonists.
Translated title of the contributionPotential therapeutic uses of opioid antagonists: Pathophysiology and preclinical evidence
Original languageSpanish
Pages (from-to)322-358
JournalRevista Colombiana de Ciencias Químico - Farmacéuticas
Volume44
Issue number3
DOIs
StatePublished - 2015

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