Postprandial lipemia induces endothelial dysfunction and higher insulin resistance in healthy subjects

Robinson Ramírez-Vélez

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective: To assess the effect of postprandial lipemia on endothelial function, insulin resistance, and lipid profile in healthy subjects. Patients and methods: A prospective', interventional study in 14 healthy young men aged 18-25 years who were given a high-fat meal. Endothelial function was measured using flow-mediated dilation (FMD) in the brachial artery, flow velocity, mean arterial pressure and serum nitrite/nitrate levels (NO 2/NO 3). Glucose, insulin, total cholesterol, and triglyceride levels were also tested. Insulin resistance was determined by calculating the HOMA-IR index (Homeostatic Model Assessment-Insulin Resistance). Results: Baseline FMD was 5.9 ± 1.1%. Postprandial lipemia reduced endothelial function by approximately 50% in the first (3.3 ± 0.5%, p=0.03) and second (3.3 ± 0.4%, p=0.04) moment respectively. This finding was associated to an increased flow rate in the brachial artery and lower NO 2/NO 3 levels (p
Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalEndocrinologia y Nutricion
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

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