Polyautoimmunity in Sjögren Syndrome

Juan Manuel Anaya, Adriana Rojas-Villarraga, Ruben D. Mantilla, Mauricio Arcos-Burgos, Juan Camilo Sarmiento-Monroy

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Polyautoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Polyautoimmunity is a frequent condition in Sjögren syndrome (SS) and follows a grouping pattern. The most frequent ADs observed in SS are autoimmune thyroid disease, rheumatoid arthritis, and systemic lupus erythematosus. Main factors associated with polyautoimmunity in SS are tobacco smoking and some genetic variants. The study of polyautoimmunity provides important clues for elucidating the common mechanisms of autoimmne diseases (ie, the autoimmune tautology).

Original languageEnglish (US)
Pages (from-to)457-472
Number of pages16
JournalRheumatic Disease Clinics of North America
Issue number3
StatePublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Rheumatology


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