Polimorfismo del TNF- alfa en autoinmunidad y tuberculosis

Paula A Correa, Luis M. Gómez, Juan Manuel Anaya

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Polymorphism of TNF - alpha in autoimmunity and tuberculosis Tumor necrosis factor alpha (TNF-alpha ) has been incriminated in several autoimmune and infectious diseases. The influence of TNF-a -308 polymorphism was examined in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjögren's syndrome (pSS) and tuberculosis. Genomic DNA from patients with RA (N=165), SLE (N=118), pSS (N=67), tuberculosis (N=138), as well as ethnic-matched controls (N=419) were characterized for the TNF-a -308 genetic polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. TNF2 allele was associated with RA (OR: 1.6, C.I.95% 1.2-2.3, p=0.008), SLE (OR: 2.3, 95%C.I. 1.6-3.3, p
Original languageSpanish
Pages (from-to)43-51
StatePublished - Jun 1 2004
Externally publishedYes

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