Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Adriana Janneth Bermudez Quintero; Marcia Cubillos; Martha Patricia Alba; Mary Trujillo; Manuel Elkin Patarroyo

doi:10.1016/S0300-9084(03)00136-6

Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Adriana Janneth Bermudez Quintero
, Marcia Cubillos
, Martha Patricia Alba
, Mary Trujillo
, Manuel Elkin Patarroyo

School of Medicine and Health Sciences

Research output: Contribution to Journal › Research Article › peer-review

16 Scopus citations

Abstract

Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.

Original language	English (US)
Article number	7
Pages (from-to)	651
Number of pages	657
Journal	Biochimie
Volume	85
Issue number	7
DOIs	https://doi.org/10.1016/S0300-9084(03)00136-6
State	Published - Jul 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 1 No Poverty
SDG 3 Good Health and Well-being

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General

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10.1016/S0300-9084(03)00136-6

Cite this

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title = "Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria",

abstract = "Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.",

author = "\{Bermudez Quintero\}, \{Adriana Janneth\} and Marcia Cubillos and Alba, \{Martha Patricia\} and Mary Trujillo and Patarroyo, \{Manuel Elkin\}",

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T1 - Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

AU - Bermudez Quintero, Adriana Janneth

AU - Cubillos, Marcia

AU - Alba, Martha Patricia

AU - Trujillo, Mary

AU - Patarroyo, Manuel Elkin

PY - 2003/7

Y1 - 2003/7

N2 - Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.

AB - Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides' secondary structure and their function as immunogen against malaria.

UR - http://www.sciencedirect.com/science/article/pii/S0300908403001366?via%3Dihub

U2 - 10.1016/S0300-9084(03)00136-6

DO - 10.1016/S0300-9084(03)00136-6

M3 - Research Article

SN - 0300-9084

VL - 85

SP - 651

JO - Biochimie

JF - Biochimie

IS - 7

M1 - 7

ER -

Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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