Pinning Control to Regulate Cellular Response in Cancer for the p53-Mdm2 Genetic Regulatory Network.

Oscar Javier  Suárez Sierra; Carlos Jesus Vega Perez; Edgar Nelson Sánchez Camperos; Guanrong  Chen; Ana E. González-Santiago

doi:10.1007/978-3-031-04379-6_6

Pinning Control to Regulate Cellular Response in Cancer for the p53-Mdm2 Genetic Regulatory Network.

Oscar Javier Suárez Sierra, Carlos Jesus Vega Perez, Edgar Nelson Sánchez Camperos, Guanrong Chen, Ana E. González-Santiago

Research output: Chapter in Book/Inform › Chapter › Research

Abstract

This chapter presents the pinning control strategy applied to the p53-Mdm2 regulatory network to achieve a target cellular response in cancer cells. The network, regulated by p300 and HDAC1, is modeled by a system of 14 ordinary differential equations. Based on this model, an oncogenic condition of Mdm2 overexpression is derived and the functional suppression of p53 is simulated as one possible carcinogenic behavior. Then, control action is introduced to induce an increased expression of p53 levels and downregulation of Mdm2 and p53 activation using only three controlled states (pinned nodes) of the network for the first case and two states for the second case, respectively. The analytic results are simulated, which illustrate the feasibility of the proposed control scheme.

Original language	Spanish (Colombia)
Title of host publication	Cancer, Complexity, Computation
Place of Publication	Suiza
Publisher	Springer
Chapter	6
Pages	133
Number of pages	155
ISBN (Electronic)	978-3-031-04379-6
ISBN (Print)	9783031043789
DOIs	https://doi.org/10.1007/978-3-031-04379-6_6
State	Published - Aug 12 2022

All Science Journal Classification (ASJC) codes

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-031-04379-6_6

https://link-springer-com.ez.urosario.edu.co/chapter/10.1007/978-3-031-04379-6_6

Cite this

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title = "Pinning Control to Regulate Cellular Response in Cancer for the p53-Mdm2 Genetic Regulatory Network.",

abstract = "This chapter presents the pinning control strategy applied to the p53-Mdm2 regulatory network to achieve a target cellular response in cancer cells. The network, regulated by p300 and HDAC1, is modeled by a system of 14 ordinary differential equations. Based on this model, an oncogenic condition of Mdm2 overexpression is derived and the functional suppression of p53 is simulated as one possible carcinogenic behavior. Then, control action is introduced to induce an increased expression of p53 levels and downregulation of Mdm2 and p53 activation using only three controlled states (pinned nodes) of the network for the first case and two states for the second case, respectively. The analytic results are simulated, which illustrate the feasibility of the proposed control scheme.",

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T1 - Pinning Control to Regulate Cellular Response in Cancer for the p53-Mdm2 Genetic Regulatory Network.

AU - Suárez Sierra, Oscar Javier

AU - Vega Perez, Carlos Jesus

AU - Sánchez Camperos, Edgar Nelson

AU - Chen, Guanrong

AU - González-Santiago, Ana E.

PY - 2022/8/12

Y1 - 2022/8/12

N2 - This chapter presents the pinning control strategy applied to the p53-Mdm2 regulatory network to achieve a target cellular response in cancer cells. The network, regulated by p300 and HDAC1, is modeled by a system of 14 ordinary differential equations. Based on this model, an oncogenic condition of Mdm2 overexpression is derived and the functional suppression of p53 is simulated as one possible carcinogenic behavior. Then, control action is introduced to induce an increased expression of p53 levels and downregulation of Mdm2 and p53 activation using only three controlled states (pinned nodes) of the network for the first case and two states for the second case, respectively. The analytic results are simulated, which illustrate the feasibility of the proposed control scheme.

AB - This chapter presents the pinning control strategy applied to the p53-Mdm2 regulatory network to achieve a target cellular response in cancer cells. The network, regulated by p300 and HDAC1, is modeled by a system of 14 ordinary differential equations. Based on this model, an oncogenic condition of Mdm2 overexpression is derived and the functional suppression of p53 is simulated as one possible carcinogenic behavior. Then, control action is introduced to induce an increased expression of p53 levels and downregulation of Mdm2 and p53 activation using only three controlled states (pinned nodes) of the network for the first case and two states for the second case, respectively. The analytic results are simulated, which illustrate the feasibility of the proposed control scheme.

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DO - 10.1007/978-3-031-04379-6_6

M3 - Capítulo

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SP - 133

BT - Cancer, Complexity, Computation

PB - Springer

CY - Suiza

ER -