Physiological and pathological implications of laminins: From the gene to the protein

María Carolina Páez; María Julieta González; Norma C. Serrano; Yehuda Shoenfeld; Juan Manuel Anaya

doi:10.1080/08916930600911519

Physiological and pathological implications of laminins: From the gene to the protein

María Carolina Páez
, María Julieta González
, Norma C. Serrano
, Yehuda Shoenfeld
, Juan Manuel Anaya

urosario

Research output: Contribution to Journal › Research Article › peer-review

15 Scopus citations

Abstract

The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed.

Original language	English (US)
Pages (from-to)	83-94
Number of pages	12
Journal	Autoimmunity
Volume	40
Issue number	2
DOIs	https://doi.org/10.1080/08916930600911519
State	Published - 2007

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SDG 7 Affordable and Clean Energy

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1080/08916930600911519

Cite this

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title = "Physiological and pathological implications of laminins: From the gene to the protein",

abstract = "The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sj{\"o}gren{\textquoteright}s syndrome (SS) are also discussed.",

author = "P{\'a}ez, \{Mar{\'i}a Carolina\} and Gonz{\'a}lez, \{Mar{\'i}a Julieta\} and Serrano, \{Norma C.\} and Yehuda Shoenfeld and Anaya, \{Juan Manuel\}",

note = "Funding Information: This work was supported by Fundaci{\'o}n para la Promoci{\'o}n de la Investigaci{\'o}n y Tecnolog{\'i}a, Bogot{\'a} (MCP, J-MA), Universidad Aut{\'o}noma de Bucara-manga (MCP, NCS), Colombia and Fondecyt, 1050192, Chile (MJG). Publisher Copyright: {\textcopyright} 2018, Taylor and Francis Ltd. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2007",

doi = "10.1080/08916930600911519",

language = "English (US)",

volume = "40",

pages = "83--94",

journal = "Autoimmunity",

issn = "0891-6934",

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TY - JOUR

T1 - Physiological and pathological implications of laminins

T2 - From the gene to the protein

AU - Páez, María Carolina

AU - González, María Julieta

AU - Serrano, Norma C.

AU - Shoenfeld, Yehuda

AU - Anaya, Juan Manuel

N1 - Funding Information: This work was supported by Fundación para la Promoción de la Investigación y Tecnología, Bogotá (MCP, J-MA), Universidad Autónoma de Bucara-manga (MCP, NCS), Colombia and Fondecyt, 1050192, Chile (MJG). Publisher Copyright: © 2018, Taylor and Francis Ltd. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2007

Y1 - 2007

N2 - The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed.

AB - The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed.

UR - https://www.scopus.com/pages/publications/34250327154

UR - https://www.scopus.com/pages/publications/34250327154#tab=citedBy

U2 - 10.1080/08916930600911519

DO - 10.1080/08916930600911519

M3 - Research Article

C2 - 17453709

AN - SCOPUS:34250327154

SN - 0891-6934

VL - 40

SP - 83

EP - 94

JO - Autoimmunity

JF - Autoimmunity

IS - 2

ER -

Physiological and pathological implications of laminins: From the gene to the protein

Abstract

UN SDGs

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