Physiological and pathological implications of laminins: From the gene to the protein

María Carolina Páez, María Julieta González, Norma C. Serrano, Yehuda Shoenfeld, Juan Manuel Anaya

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed.

Original languageEnglish (US)
Pages (from-to)83-94
Number of pages12
JournalAutoimmunity
Volume40
Issue number2
DOIs
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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