Physiological and pathological implications of laminins: from the gene to the protein.

María Carolina Páez, María Julieta González, Norma C. Serrano, Yehuda Shoenfeld, Juan Manuel Anaya

Research output: Contribution to journalLiterature review

9 Citations (Scopus)

Abstract

The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren's syndrome (SS) are also discussed.
Original languageEnglish (US)
Pages (from-to)83-94
Number of pages12
JournalAutoimmunity
DOIs
StatePublished - Mar 1 2007

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Laminin
Proteins
Extracellular Matrix Proteins
Sjogren's Syndrome
Proteoglycans
Basement Membrane
Systemic Lupus Erythematosus
Autoimmune Diseases
Extracellular Matrix
Collagen
Pathology
Genes

Cite this

Páez, María Carolina ; González, María Julieta ; Serrano, Norma C. ; Shoenfeld, Yehuda ; Anaya, Juan Manuel. / Physiological and pathological implications of laminins: from the gene to the protein. In: Autoimmunity. 2007 ; pp. 83-94.
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abstract = "The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sj{\"o}gren's syndrome (SS) are also discussed.",
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Physiological and pathological implications of laminins: from the gene to the protein. / Páez, María Carolina; González, María Julieta; Serrano, Norma C.; Shoenfeld, Yehuda; Anaya, Juan Manuel.

In: Autoimmunity, 01.03.2007, p. 83-94.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Physiological and pathological implications of laminins: from the gene to the protein.

AU - Páez, María Carolina

AU - González, María Julieta

AU - Serrano, Norma C.

AU - Shoenfeld, Yehuda

AU - Anaya, Juan Manuel

PY - 2007/3/1

Y1 - 2007/3/1

N2 - The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren's syndrome (SS) are also discussed.

AB - The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren's syndrome (SS) are also discussed.

U2 - 10.1080/08916930600911519

DO - 10.1080/08916930600911519

M3 - Literature review

C2 - 17453709

SP - 83

EP - 94

JO - Autoimmunity

JF - Autoimmunity

SN - 0891-6934

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