Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations

Juan David Ramírez; María Clara Duque; Felipe Guhl

doi:10.1016/j.actatropica.2011.04.009

Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations

Juan David Ramírez, María Clara Duque, Felipe Guhl

Research output: Contribution to journal › Research Article › peer-review

39 Scopus citations

Abstract

Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.

Original language	English (US)
Pages (from-to)	61-65
Number of pages	5
Journal	Acta Tropica
Volume	119
Issue number	1
DOIs	https://doi.org/10.1016/j.actatropica.2011.04.009
State	Published - Jul 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology
veterinary (miscalleneous)
Insect Science
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.actatropica.2011.04.009

Cite this

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title = "Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations",

abstract = "Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.",

author = "Ram{\'i}rez, {Juan David} and Duque, {Mar{\'i}a Clara} and Felipe Guhl",

note = "Funding Information: Financial support was provided by the Project Chagas EpiNet from The European Union Seventh Framework Programme, contract No. 223034. We thank the research fund of the faculty of sciences from the Universidad de los Andes and the group of parasitology from the Instituto Nacional de Salud in Colombia for providing some human isolates.",

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AU - Duque, María Clara

AU - Guhl, Felipe

N1 - Funding Information: Financial support was provided by the Project Chagas EpiNet from The European Union Seventh Framework Programme, contract No. 223034. We thank the research fund of the faculty of sciences from the Universidad de los Andes and the group of parasitology from the Instituto Nacional de Salud in Colombia for providing some human isolates.

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N2 - Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.

AB - Chagas disease caused by Trypanosoma cruzi comprises an important problem of public health in the Americas. This parasite has been recently divided into six Discrete Typing Units (DTUs) due to its high genetic diversity. We sequenced the Cytochorme b (Cytb) gene of 70 T. cruzi I Colombian clones finding four genotypes related to transmission cycles of Chagas disease in Colombia and also to specific hosts of T. cruzi. The genotypes herein described based on Cytb gene sequences are in accordance with those found using the mini-exon gene and reveals once again the enormous genetic diversity at sub-DTU level evidenced in T. cruzi I.

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Phylogenetic reconstruction based on Cytochrome b (Cytb) gene sequences reveals distinct genotypes within Colombian Trypanosoma cruzi I populations

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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