On the crystal structures and hydrogen bond patterns in proline pseudopolymorphs

Luis E. Seijas, Gerzon E. Delgado, Asiloé J. Mora, Andrew N. Fitch, Michela Brunelli

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Amino acids often cocrystallize with water molecules, which make them pseudopolymorphs of their anhydrous forms. In this work, we discuss in detail the hydrogen bond patterns in anhydrous L-proline and DL-proline and its pseudopolymorphic forms: L-proline monohydrate and DL-proline monohydrate. For this propose, the crystal structure of L-proline anhydrous was determined from synchrotron X-ray powder diffraction data and refined using the Rietveld method. Special emphasis is given to the role played by the water molecule in the hydrogen bond network observed in the crystalline structures.

Original languageEnglish (US)
Article number017003PDJ
Pages (from-to)235-240
Number of pages6
JournalPowder Diffraction
Issue number3
StatePublished - Sep 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiation
  • General Materials Science
  • Instrumentation
  • Condensed Matter Physics


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