Toxoplasmosis ocular en Colombia: 10 años de aportes investigativos

Translated title of the contribution: Ocular toxoplasmosis in Colombia: 10 years of research contributions

Ligia Alejandra Delatorre Cifuentes, león andrés facio lince, Clara López de Mesa

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To describe research contributions in ocular toxoplasmosis
performed in Colombia.
Method: We conducted a narrative review of the literature on ocular
toxoplasmosis (OT) in Colombia between 2007 and 2017 on aspects related to
the parasite and to the host. Published reviews were included, as well as all the
original articles related to various topics: epidemiological, immunological, clinical,
diagnostic and therapeutic through PubMed using the MeSH terms, with the
following syntax: “(((Colombia [Affi liation]) OR colombia [MeSH Terms]) OR
south america [MeSH Terms]) AND “toxoplasmosis, ocular” [MeSH Terms] AND
(“2007/01/01” [PDAT]: “2017/12/31” [PDAT]). Hand searches were also conducted.
Results: In the literature search with the MESH terms, 36 articles were found,
distributed in the territory with 10 in Colombia and 26 in the rest of South America.
Important diff erences were found in the relationship between the parasite and the
host when comparing Colombia with the rest of the world. Th e strains in Colombia
are more virulent (Type I / III and atypical) and we found a high prevalence of
positive titers and development of OT in the country, with water and meat products
as one of the main means of contagion. Th e importance of peptides that triggered
the humoral immune response in patients was determined. Signifi cant diff erences
were found in the clinical severity (with Colombian patients experiencing a
greater size of lesions, degree of infl ammation, macular involvement, bilateral
involvement, and recurrences) related to the infl ammatory response produced in
the host, associated with a decrease in intraocular levels of IFN-γ / IL-17 and an
increase of IL-6 / Il-13. In Colombian patients, ocular cytokinome is related to
clinical features, presenting a Th 2 response related to severe ocular involvement.
Conclusion: Research contributions of OT in Colombia have been of global
importance, allowing to know more about the type of parasite, the epidemiology,
the clinical presentation, the immune response.
Translated title of the contributionOcular toxoplasmosis in Colombia: 10 years of research contributions
Original languageSpanish (Colombia)
Pages (from-to)11-22
Number of pages11
JournalRevista Sociedad Colombiana De Oftalmología
Volume51
Issue number1
StatePublished - May 8 2018

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