Necrotizing Anterior Scleritis in a Woman with Terrien’s Marginal Degeneration: A Case Report

Maria Alejandra Fonseca-Mora, Paula Tatiana Muñoz-Vargas, Juliana Reyes-Guanes, William Andrés Rojas Carabalí, Miguel Cuevas, Ligia Alejandra De la Torre Cifuentes

Research output: Contribution to journalResearch Articlepeer-review


Purpose: The aim of the study was to report the first case of a patient with Terrien’s Marginal Degeneration (TMD) who developed necrotizing anterior scleritis without systemic disease association, requiring systemic immunosuppressive treatment. Case Report: A 32-year-old female consulted for bilateral ocular burning and hyperemia. Initially, she was diagnosed with conjunctivitis and treated with topical antibiotics and corticosteroids, with mild transitory improvement but the progression of the disease. Years later, she attended the ocular immunology consultation for a second opinion where TMD with ocular inflammatory component OU was diagnosed. Seven months later, she presented with severe pain, decreased visual acuity, and photophobia in OS. At the slit-lamp examination, necrotizing anterior scleritis with a high risk of perforation in OS was observed. The patient was referred to the rheumatologist and started treatment with systemic corticosteroids and cyclophosphamide, exhibiting a clinical improvement. The patient did not meet the criteria for any systemic illness associated with scleritis, such as autoimmune diseases or vasculitis. Thus, scleritis was related to the adjacent inflammatory process associated with TMD, as an atypical presentation of this disease. Conclusion: Although an inflammatory type of TMD has been proposed, it is essential to follow up closely these patients and consider necrotizing anterior scleritis, a severe ocular disease that requires prompt immunosuppressive management, as a possible atypical associated presentation of this disease.
Original languageEnglish (US)
Pages (from-to)318
Number of pages321
JournalOpen Ophthalmology Journal
StatePublished - Dec 31 2021

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • General Medicine


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