Modelado y simulación de la repolarización ventricular u onda T del ECG de individuos con diabetes tipo 1 durante infusión de adrenalina

Translated title of the contribution: Modeling and simulation of ventricular repolarization or T-wave of ECG of subjects with type 1 diabetes during adrenaline infusions

O. J. Perdomo, C. A. Perdomo, J. L. Marques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Increased catecholamine activity, both endogenous, and through medications, it has long been recognized to increase the risk of cardiac death. This paper proposes the use of the Bueno-Orovio - Cherry - Fenton model to understand the behavior of ventricular cells: Endocardium, Myocardium and Epicardial, through the transmural ECG generated by the weighted sum of action potentials of the three ventricular cells. These results were validated with a dataset of Vectorcardiograms according to Frank VCG-lead system (X, Y, Z) of 22 subjects with type 1 diabetes along adrenaline infusion, aged 20 to 40 years. Moreover, it was analyzed all 12-lead ECG, calculated from VCG's by using the transform Dower. Finally, due to the sensitivity of the potassium current in the myocardium cells and the simulated transmural ECG, decrements considerably bigger than those used in this study could generate early afterdepolarization (EAD), flattening and inversion of the T-wave.

Translated title of the contributionModeling and simulation of ventricular repolarization or T-wave of ECG of subjects with type 1 diabetes during adrenaline infusions
Original languageSpanish
Title of host publication2013 Pan American Health Care Exchanges, PAHCE 2013 - Conference, Workshops, and Exhibits. Cooperation / Linkages
Subtitle of host publicationAn Independent Forum for Patient Care and Technology Support
DOIs
StatePublished - 2013
Externally publishedYes
Event8th Pan American Health Care Exchanges Conference, PAHCE 2013 - Medellin, Colombia
Duration: Apr 29 2013May 4 2013

Publication series

NamePan American Health Care Exchanges, PAHCE
ISSN (Print)2327-8161
ISSN (Electronic)2327-817X

Conference

Conference8th Pan American Health Care Exchanges Conference, PAHCE 2013
CountryColombia
CityMedellin
Period4/29/135/4/13

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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