TY - GEN
T1 - Modelado y simulación de la repolarización ventricular u onda T del ECG de individuos con diabetes tipo 1 durante infusión de adrenalina
AU - Perdomo, O. J.
AU - Perdomo, C. A.
AU - Marques, J. L.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - Increased catecholamine activity, both endogenous, and through medications, it has long been recognized to increase the risk of cardiac death. This paper proposes the use of the Bueno-Orovio - Cherry - Fenton model to understand the behavior of ventricular cells: Endocardium, Myocardium and Epicardial, through the transmural ECG generated by the weighted sum of action potentials of the three ventricular cells. These results were validated with a dataset of Vectorcardiograms according to Frank VCG-lead system (X, Y, Z) of 22 subjects with type 1 diabetes along adrenaline infusion, aged 20 to 40 years. Moreover, it was analyzed all 12-lead ECG, calculated from VCG's by using the transform Dower. Finally, due to the sensitivity of the potassium current in the myocardium cells and the simulated transmural ECG, decrements considerably bigger than those used in this study could generate early afterdepolarization (EAD), flattening and inversion of the T-wave.
AB - Increased catecholamine activity, both endogenous, and through medications, it has long been recognized to increase the risk of cardiac death. This paper proposes the use of the Bueno-Orovio - Cherry - Fenton model to understand the behavior of ventricular cells: Endocardium, Myocardium and Epicardial, through the transmural ECG generated by the weighted sum of action potentials of the three ventricular cells. These results were validated with a dataset of Vectorcardiograms according to Frank VCG-lead system (X, Y, Z) of 22 subjects with type 1 diabetes along adrenaline infusion, aged 20 to 40 years. Moreover, it was analyzed all 12-lead ECG, calculated from VCG's by using the transform Dower. Finally, due to the sensitivity of the potassium current in the myocardium cells and the simulated transmural ECG, decrements considerably bigger than those used in this study could generate early afterdepolarization (EAD), flattening and inversion of the T-wave.
UR - http://www.scopus.com/inward/record.url?scp=84884316303&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884316303&partnerID=8YFLogxK
U2 - 10.1109/PAHCE.2013.6568237
DO - 10.1109/PAHCE.2013.6568237
M3 - Contribución a la conferencia
AN - SCOPUS:84884316303
SN - 9781467362559
T3 - Pan American Health Care Exchanges, PAHCE
BT - 2013 Pan American Health Care Exchanges, PAHCE 2013 - Conference, Workshops, and Exhibits. Cooperation / Linkages
T2 - 8th Pan American Health Care Exchanges Conference, PAHCE 2013
Y2 - 29 April 2013 through 4 May 2013
ER -