Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region

Milena Camargo, Sara C Soto-De León, Luisa Del Río-Ospina, Astrid C Páez, Zanony González, Edgardo González, Juan R Cubides, Paola A Camargo-Ayala, Manuel E Patarroyo, Manuel A Patarroyo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2% of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0%), followed by P. malariae (43.2%), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas.

Original languageEnglish (US)
Pages (from-to)5543
Number of pages14
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Apr 3 2018
Externally publishedYes

Cite this

Camargo, Milena ; Soto-De León, Sara C ; Del Río-Ospina, Luisa ; Páez, Astrid C ; González, Zanony ; González, Edgardo ; Cubides, Juan R ; Camargo-Ayala, Paola A ; Patarroyo, Manuel E ; Patarroyo, Manuel A. / Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region. In: Scientific Reports. 2018 ; Vol. 8, No. 1. pp. 5543.
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abstract = "Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2{\%} of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0{\%}), followed by P. malariae (43.2{\%}), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas.",
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Camargo, M, Soto-De León, SC, Del Río-Ospina, L, Páez, AC, González, Z, González, E, Cubides, JR, Camargo-Ayala, PA, Patarroyo, ME & Patarroyo, MA 2018, 'Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region', Scientific Reports, vol. 8, no. 1, pp. 5543. https://doi.org/10.1038/s41598-018-23801-9

Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region. / Camargo, Milena; Soto-De León, Sara C; Del Río-Ospina, Luisa; Páez, Astrid C; González, Zanony; González, Edgardo; Cubides, Juan R; Camargo-Ayala, Paola A; Patarroyo, Manuel E; Patarroyo, Manuel A.

In: Scientific Reports, Vol. 8, No. 1, 03.04.2018, p. 5543.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region

AU - Camargo, Milena

AU - Soto-De León, Sara C

AU - Del Río-Ospina, Luisa

AU - Páez, Astrid C

AU - González, Zanony

AU - González, Edgardo

AU - Cubides, Juan R

AU - Camargo-Ayala, Paola A

AU - Patarroyo, Manuel E

AU - Patarroyo, Manuel A

PY - 2018/4/3

Y1 - 2018/4/3

N2 - Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2% of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0%), followed by P. malariae (43.2%), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas.

AB - Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2% of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0%), followed by P. malariae (43.2%), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas.

U2 - 10.1038/s41598-018-23801-9

DO - 10.1038/s41598-018-23801-9

M3 - Article

C2 - 29615693

VL - 8

SP - 5543

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

ER -

Camargo M, Soto-De León SC, Del Río-Ospina L, Páez AC, González Z, González E et al. Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region. Scientific Reports. 2018 Apr 3;8(1):5543. https://doi.org/10.1038/s41598-018-23801-9