Mechanisms of genetically-based resistance to malaria

Carolina López, Carolina Saravia, Andromeda Gomez, Johan Hoebeke, Manuel A. Patarroyo

Research output: Contribution to journalLiterature review

78 Citations (Scopus)

Abstract

Malaria remains one of the most prevalent parasitoses worldwide. About 350 to 500. million febrile episodes are observed yearly in African children alone and more than 1. million people die because of malaria each year. Multiple factors have hampered the effective control of this disease, some of which include the complex biology of the Plasmodium parasites, their high polymorphism and their increasingly high resistance to antimalarial drugs, mainly in endemic regions. The ancient interaction between malarial parasites and humans has led to the fixation in the population of several inherited alterations conferring protection against malaria. Some of the mechanisms underlying protection against this disease are described in this review for hemoglobin-inherited disorders (thalassemia, sickle-cell trait, HbC and HbE), erythrocyte polymorphisms (ovalocytosis and Duffy blood group), enzymopathies (G6PD deficiency and PK deficiency) and immunogenetic variants (HLA alleles, complement receptor 1, NOS2, tumor necrosis factor-Α promoter and chromosome 5q31-q33 polymorphisms). © 2010 Elsevier B.V.
Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalGene
DOIs
StatePublished - Nov 1 2010

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Malaria
Parasites
Sickle Cell Trait
Complement C1
Glucosephosphate Dehydrogenase Deficiency
Complement Receptors
Immunogenetics
Thalassemia
Plasmodium
Antimalarials
Blood Group Antigens
Hemoglobins
Fever
Tumor Necrosis Factor-alpha
Chromosomes
Erythrocytes
Alleles
Population
Pyruvate Kinase Deficiency of Red Cells

Cite this

López, Carolina ; Saravia, Carolina ; Gomez, Andromeda ; Hoebeke, Johan ; Patarroyo, Manuel A. / Mechanisms of genetically-based resistance to malaria. In: Gene. 2010 ; pp. 1-12.
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Mechanisms of genetically-based resistance to malaria. / López, Carolina; Saravia, Carolina; Gomez, Andromeda; Hoebeke, Johan; Patarroyo, Manuel A.

In: Gene, 01.11.2010, p. 1-12.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - Mechanisms of genetically-based resistance to malaria

AU - López, Carolina

AU - Saravia, Carolina

AU - Gomez, Andromeda

AU - Hoebeke, Johan

AU - Patarroyo, Manuel A.

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Malaria remains one of the most prevalent parasitoses worldwide. About 350 to 500. million febrile episodes are observed yearly in African children alone and more than 1. million people die because of malaria each year. Multiple factors have hampered the effective control of this disease, some of which include the complex biology of the Plasmodium parasites, their high polymorphism and their increasingly high resistance to antimalarial drugs, mainly in endemic regions. The ancient interaction between malarial parasites and humans has led to the fixation in the population of several inherited alterations conferring protection against malaria. Some of the mechanisms underlying protection against this disease are described in this review for hemoglobin-inherited disorders (thalassemia, sickle-cell trait, HbC and HbE), erythrocyte polymorphisms (ovalocytosis and Duffy blood group), enzymopathies (G6PD deficiency and PK deficiency) and immunogenetic variants (HLA alleles, complement receptor 1, NOS2, tumor necrosis factor-Α promoter and chromosome 5q31-q33 polymorphisms). © 2010 Elsevier B.V.

AB - Malaria remains one of the most prevalent parasitoses worldwide. About 350 to 500. million febrile episodes are observed yearly in African children alone and more than 1. million people die because of malaria each year. Multiple factors have hampered the effective control of this disease, some of which include the complex biology of the Plasmodium parasites, their high polymorphism and their increasingly high resistance to antimalarial drugs, mainly in endemic regions. The ancient interaction between malarial parasites and humans has led to the fixation in the population of several inherited alterations conferring protection against malaria. Some of the mechanisms underlying protection against this disease are described in this review for hemoglobin-inherited disorders (thalassemia, sickle-cell trait, HbC and HbE), erythrocyte polymorphisms (ovalocytosis and Duffy blood group), enzymopathies (G6PD deficiency and PK deficiency) and immunogenetic variants (HLA alleles, complement receptor 1, NOS2, tumor necrosis factor-Α promoter and chromosome 5q31-q33 polymorphisms). © 2010 Elsevier B.V.

U2 - 10.1016/j.gene.2010.07.008

DO - 10.1016/j.gene.2010.07.008

M3 - Literature review

SP - 1

EP - 12

JO - Gene

JF - Gene

SN - 0378-1119

ER -