Mechanism of action of Type 2 Sodium-Glucose Cotransporter Inhibitors: Beyond glycaemic control: Más allá del control de la glicemia

Translated title of the contribution: Mechanism of action of Type 2 Sodium-Glucose Cotransporter Inhibitors: Beyond glycaemic control

Andrés Felipe Buitrago Sandoval, Carlos Andrés Sánchez Vallejo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Type 2 Sodium-Glucose Cotransporter (SGLT2) Inhibitors exercise their glucose-lowering effect through the inhibition of glucose reabsorption in the kidney. However, the cardiovascular and renal effects, as well as in those of cardiac failure, seem to occur independently from the glucose–lowering effects of these drugs. The principal mechanisms of action that explain their cardiovascular benefits are the hypotensive effect and the decrease in fill pressures, as well as direct effects on the metabolism of the myocardial cell. There is also a reduction in the urine albumin, as well as non-glycaemic effects, and a decrease in adipose tissue, with an increase in haematocrit and urine uric acid. Each one of these novel mechanisms is described in this article.

Translated title of the contributionMechanism of action of Type 2 Sodium-Glucose Cotransporter Inhibitors: Beyond glycaemic control
Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalRevista Colombiana de Cardiologia
Volume27
DOIs
StatePublished - Mar 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Concepts

  • Concept
  • Albumin
  • Sodium glucose cotransporter inhibitor
  • Uric acid
  • Adipose tissue
  • Antidiarrheal activity
  • Antihypertensive activity
  • Article
  • Cardiac muscle cell
  • Cell metabolism
  • Drug mechanism
  • Human
  • Uric acid urine level
  • Heart failure
  • Treatment
  • Diabetes

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