Manifestaciones relacionadas con alteraciones en la coagulación en lupus eritematoso sistémico de inicio juvenil. Reporte de casos y revisión de la literatura

Translated title of the contribution: Manifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review

María Fernanda Reina Ávila, Lina María Saza Mejía, Pilar del Rosario Guarnizo Zuccardi, Lyda Rengifo, Sandra Patricia Garcés Sterling

Research output: Contribution to journalArticlepeer-review

Abstract

Haematological alterations are common in patients with systemic lupus erythematosus (SLE). These haematological manifestations may be expressed related to the involvement of cells affected and coagulation changes. The compromise in coagulation is associated with thrombotic manifestations. Risk factors associated with thrombosis have been described, such as the presence of elevated levels of homocysteine, acquired deficit of protein S, protein C, and antithrombin. However, the haemorrhagic diathesis has also been described at a lower frequency and related to the acquired deficiency of coagulation factors caused by the development of autoantibodies directed against coagulation factors. The cases are presented of 3 patients with juvenile SLE with unusual haematological manifestations, as well as a review of the literature in relation to them. The haematological manifestations in juvenile SLE are not only related to alterations in cell lines, vascular thrombosis and bleeding disorders should also be suspected. Early diagnosis and treatment reduces morbidity and mortality related to this type of manifestations.

Translated title of the contributionManifestations related to alterations in coagulation in systemic lupus erythematosus of juvenile onset. Case report and literature review
Original languageSpanish
Pages (from-to)190-201
Number of pages12
JournalRevista Colombiana de Reumatologia
Volume27
Issue number3
DOIs
StatePublished - Jul 1 2020

All Science Journal Classification (ASJC) codes

  • Rheumatology

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