Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population

L. M. Gómez, E. Sánchez, E. A. Ruiz-Narvaez, M. A. López-Nevot, J. M. Anaya, J. Martín

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic. Functional promoter variants in the MIF gene influence susceptibility to inflammatory diseases in Caucasians and Africans. An association study was carried out to examine the influence of MIF -173 single nucleotide polymorphism and the MIF -794 microsatellite on the susceptibility to develop human tuberculosis (TB) in a well-defined Latin-American population. To this purpose, 230 northwestern Colombian patients with pulmonary TB, negative for human immunodeficiency virus infection, and 235 matched healthy individuals stratified by the tuberculin skin test were examined. Multivariate analysis showed that MIF -173C allele was associated with disease (odds ratio = 1.64, 95% confidence interval 1.07-2.52) in a dominant pattern. No allele in the MIF -794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalTissue Antigens
Volume70
Issue number1
DOIs
StatePublished - Jul 2007

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Fingerprint Dive into the research topics of 'Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population'. Together they form a unique fingerprint.

Cite this