Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate

C.A. Mastronardi, E. Pillai, D.A. Pineda, A.F. Martinez, F. Lopera, J.I. Velez, J.D. Palacio, H. Patel, S. Easteal, M.T. Acosta, F.X. Castellanos, M. Muenke, M. Arcos-Burgos

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurodevelopmental disorder with serious long-term repercussions. Despite being one of the most common cognitive disorders, the clinical diagnosis of ADHD is based on subjective assessments of perceived behaviors. Endophenotypes (neurobiological markers that cosegregate and are associated with an illness) are thought to provide a more powerful and objective framework for revealing the underlying neurobiology than syndromic psychiatric classification. Here, we present the results of applying genetic linkage and association analyses to neuropsychological endophenotypes using microsatellite and single nucleotide polymorphisms. We found several new genetic regions linked and/or associated with these endophenotypes, and others previously associated to ADHD, for example, loci harbored in the LPHN3, FGF1, POLR2A, CHRNA4 and ANKFY1 genes. These findings, when compared with those linked and/or associated to ADHD, suggest that these endophenotypes lie on shared pathways. The genetic information provided by this study offers a novel and complementary method of assessing the genetic causes underpinning the susceptibility to behavioral conditions and may offer new insights on the neurobiology of the disorder. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Original languageEnglish (US)
Pages (from-to)1434-1440
Number of pages7
JournalMolecular Psychiatry
Volume21
Issue number10
DOIs
StatePublished - 2016

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Endophenotypes
Attention Deficit Disorder with Hyperactivity
Pedigree
Neurobiology
Fibroblast Growth Factor 1
Genetic Linkage
Microsatellite Repeats
Single Nucleotide Polymorphism
Psychiatry
Genes

Cite this

Mastronardi, C. A., Pillai, E., Pineda, D. A., Martinez, A. F., Lopera, F., Velez, J. I., ... Arcos-Burgos, M. (2016). Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate. Molecular Psychiatry, 21(10), 1434-1440. https://doi.org/10.1038/mp.2015.172
Mastronardi, C.A. ; Pillai, E. ; Pineda, D.A. ; Martinez, A.F. ; Lopera, F. ; Velez, J.I. ; Palacio, J.D. ; Patel, H. ; Easteal, S. ; Acosta, M.T. ; Castellanos, F.X. ; Muenke, M. ; Arcos-Burgos, M. / Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate. In: Molecular Psychiatry. 2016 ; Vol. 21, No. 10. pp. 1434-1440.
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Mastronardi, CA, Pillai, E, Pineda, DA, Martinez, AF, Lopera, F, Velez, JI, Palacio, JD, Patel, H, Easteal, S, Acosta, MT, Castellanos, FX, Muenke, M & Arcos-Burgos, M 2016, 'Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate', Molecular Psychiatry, vol. 21, no. 10, pp. 1434-1440. https://doi.org/10.1038/mp.2015.172

Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate. / Mastronardi, C.A.; Pillai, E.; Pineda, D.A.; Martinez, A.F.; Lopera, F.; Velez, J.I.; Palacio, J.D.; Patel, H.; Easteal, S.; Acosta, M.T.; Castellanos, F.X.; Muenke, M.; Arcos-Burgos, M.

In: Molecular Psychiatry, Vol. 21, No. 10, 2016, p. 1434-1440.

Research output: Contribution to journalArticle

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AU - Mastronardi, C.A.

AU - Pillai, E.

AU - Pineda, D.A.

AU - Martinez, A.F.

AU - Lopera, F.

AU - Velez, J.I.

AU - Palacio, J.D.

AU - Patel, H.

AU - Easteal, S.

AU - Acosta, M.T.

AU - Castellanos, F.X.

AU - Muenke, M.

AU - Arcos-Burgos, M.

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N2 - Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurodevelopmental disorder with serious long-term repercussions. Despite being one of the most common cognitive disorders, the clinical diagnosis of ADHD is based on subjective assessments of perceived behaviors. Endophenotypes (neurobiological markers that cosegregate and are associated with an illness) are thought to provide a more powerful and objective framework for revealing the underlying neurobiology than syndromic psychiatric classification. Here, we present the results of applying genetic linkage and association analyses to neuropsychological endophenotypes using microsatellite and single nucleotide polymorphisms. We found several new genetic regions linked and/or associated with these endophenotypes, and others previously associated to ADHD, for example, loci harbored in the LPHN3, FGF1, POLR2A, CHRNA4 and ANKFY1 genes. These findings, when compared with those linked and/or associated to ADHD, suggest that these endophenotypes lie on shared pathways. The genetic information provided by this study offers a novel and complementary method of assessing the genetic causes underpinning the susceptibility to behavioral conditions and may offer new insights on the neurobiology of the disorder. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

AB - Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurodevelopmental disorder with serious long-term repercussions. Despite being one of the most common cognitive disorders, the clinical diagnosis of ADHD is based on subjective assessments of perceived behaviors. Endophenotypes (neurobiological markers that cosegregate and are associated with an illness) are thought to provide a more powerful and objective framework for revealing the underlying neurobiology than syndromic psychiatric classification. Here, we present the results of applying genetic linkage and association analyses to neuropsychological endophenotypes using microsatellite and single nucleotide polymorphisms. We found several new genetic regions linked and/or associated with these endophenotypes, and others previously associated to ADHD, for example, loci harbored in the LPHN3, FGF1, POLR2A, CHRNA4 and ANKFY1 genes. These findings, when compared with those linked and/or associated to ADHD, suggest that these endophenotypes lie on shared pathways. The genetic information provided by this study offers a novel and complementary method of assessing the genetic causes underpinning the susceptibility to behavioral conditions and may offer new insights on the neurobiology of the disorder. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

U2 - 10.1038/mp.2015.172

DO - 10.1038/mp.2015.172

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