LDH-A and α-actin as tools to assess the effects of temperature on the vertebrate genome: Some problems

Oliver Clay, Stilianos Arhondakis, Giuseppe D'Onofrio, Giorgio Bernardi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In a recent paper written with the purpose of shedding light on the question of whether genomic GC levels are related to temperature in vertebrates, Ream et al. [Mol. Biol. Evol. 20 (2003) 105] offered an analysis of two sets of homologous genes: those coding for α-actin and lactate dehydrogenase-A (LDH-A). The conclusion was that "there is no consistent relationship between adaptation temperature and the percentage of thermal stability-enhancing G+C base pairs in protein-coding genes". We argue here that the data presented neither prove nor suggest such a conclusion because of conceptual and methodological errors.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalGene
Volume317
Issue number1-2
DOIs
StatePublished - Oct 23 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

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