Latent Rheumatic, Thyroid and Phospholipid Autoimmunity in Hospitalized Patients with COVID-19

Juan Manuel Anaya, Diana M. Monsalve, Manuel Rojas, Yhojan Rodríguez, Norma Montoya-García, Laura Milena Mancera-Navarro, Ana María Villadiego-Santana, Giovanni Rodríguez-Leguizamón, Yeny Acosta-Ampudia, Carolina Ramírez-Santana

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Autoimmune responses mediated by autoantibodies have been observed in SARS-CoV-2 infection. Herein, we evaluate the presence of rheumatic, thyroid and phospholipid autoantibodies in sera samples from 120 adult hospitalized patients with COVID-19 in comparison to pre-pandemic samples from 100 healthy individuals. In addition, to estimate the frequency of these autoantibodies in COVID-19, a meta-analysis of selected articles was conducted. Hospitalized patients with COVID-19 had latent autoimmunity characterized by a high frequency of anti-thyroid peroxidase antibodies, rheumatoid factor (RF), anti-cyclic citrullinated peptide third generation antibodies, antinuclear antibodies (ANAs), IgM anti-β2-glycoprotein I (β2GP1) and IgM anti-cardiolipin antibodies. The meta-analysis confirmed our results, with RF and ANAs being the most common autoantibodies. In addition, cluster analysis revealed that those patients with high frequency of RF, IgM anti-β2GP1 antibodies and ANAs had a longer hospital stay, required more vasopressors during hospitalization, and were more likely to develop critical disease. These data suggest that latent autoimmunity influences the severity of COVID-19, and support further post-COVID studies in order to evaluate the development of overt autoimmunity.

Original languageEnglish (US)
Article number100091
Pages (from-to)100091
JournalJournal of Translational Autoimmunity
StateE-pub ahead of print - Mar 2 2021

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy


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