Laminin as a Biomarker of Blood–Brain Barrier Disruption under Neuroinflammation: A Systematic Review

Juan Felipe Zapata Acevedo, Valentina García Pérez, Ricardo Cabezas Pérez, Monica Losada Barragán, Jeinny Karina Vargas Sanchez, Rodrigo Esteban Gonzalez Reyes

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Laminin, a non-collagenous glycoprotein present in the brain extracellular matrix, helps to maintain blood–brain barrier (BBB) integrity and regulation. Neuroinflammation can compromise laminin structure and function, increasing BBB permeability. The aim of this paper is to determine if neuroinflammation-induced laminin functional changes may serve as a potential biomarker of
alterations in the BBB. The 38 publications included evaluated neuroinflammation, BBB disruption, and laminin, and were assessed for quality and risk of bias (protocol registered in PROSPERO; CRD42020212547). We found that laminin may be a good indicator of BBB overall structural integrity, although changes in expression are dependent on the pathologic or experimental model used. In ischemic stroke, permanent vascular damage correlates with increased laminin expression (β and γ subunits), while transient damage correlates with reduced laminin expression (α subunits). Laminin was reduced in traumatic brain injury and cerebral hemorrhage studies but increased in multiple sclerosis and status epilepticus studies. Despite these observations, there is limited knowledge about the role played by different subunits or isoforms (such as 411 or 511) of laminin in maintaining structural architecture of the BBB under neuroinflammation. Further studies may clarify this aspect and the possibility of using laminin as a biomarker in different pathologies, which have alterations in BBB function in common.
Translated title of the contributionLaminina como biomarcador de la alteración de la barrera hematoencefálica bajo neuroinflamación: una revisión sistemática
Original languageEnglish (US)
JournalInternational Journal of Molecular Sciences
Volume23
Issue number12
DOIs
StatePublished - Jun 17 2022

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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