Lactato sérico en urgencias como factor pronóstico en pacientes con sepsis sin hipotensión

Translated title of the contribution: Serum lactate in the emergency department as a prognostic factor in patients with sepsis without hypotension

Jessica Londoño, Alba Luz León, Ferney Rodríguez, Lena Barrera, Gisela De La Rosa, Rodolfo Dennis, Carmelo Dueñas, Marcela Granados, Dario Londoño, Francisco Molina, Guillermo Ortiz, Fabián Jaimes

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background and objective: The relationship between lactate and mortality in patients without hypotension has not been appropriately explored. Our aim was to determine the usefulness of serum lactate as a prognostic factor of 28-day mortality in patients admitted to the Emergency Department with clinical diagnosis of sepsis without septic shock. Patients and methods: We performed a secondary analysis of the study The epidemiology of sepsis in Colombia, a prospective cohort of patients from 10 general hospitals in 4 Colombian cities. We analyzed patients without hypotension with serum lactate available and admitted with community-acquired infections, which were confirmed according to the Centers for Disease Control and Prevention CDC criteria. A logistical regression was performed adjusting for age, sex, comorbidities and severity scores. Results: We included 961 patients aged 57.2 ± 21.0 years, 54.2% were females, mean SOFA score was 3.0 ± 2.3 and APACHE score was 11.1 ± 6.4. We observed a linear relationship between serum lactate and the odds of death, and after adjustment there was a significant and independent association between lactate and mortality (odds ratio 1,16, 95% confidence interval 1.02-1.33). Conclusion: Serum lactate is independently and significantly associated with 28-day mortality among patients with infection who present to the Emergency Department without hypotension. Besides, mortality increases in a linear way with serum lactate from any detectable value.

Translated title of the contributionSerum lactate in the emergency department as a prognostic factor in patients with sepsis without hypotension
Original languageSpanish
Pages (from-to)246-251
Number of pages6
JournalMedicina Clinica
Volume141
Issue number6
DOIs
StatePublished - Sep 21 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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