Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy: Systematic review

Luisa Fernanda Garciá Salazar, Gabriela Lopes Dos Santos, Silvia Letícia Pavaõ, Nelci Adriana Cicuto Ferreira Rocha, Thiago Luiz De Russo

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Objective: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP). Methods: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014. Results: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality. Conclusion: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalDevelopmental Neurorehabilitation
Volume18
Issue number1
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Rehabilitation
  • Developmental Neuroscience

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