TY - JOUR
T1 - Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy
T2 - Systematic review
AU - Garciá Salazar, Luisa Fernanda
AU - Santos, Gabriela Lopes Dos
AU - Pavaõ, Silvia Letícia
AU - Rocha, Nelci Adriana Cicuto Ferreira
AU - Russo, Thiago Luiz De
N1 - Funding Information:
The authors want to thank the fellowship provided by the Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq. L.F.G.S. was master student supported by Programa Estudantes-Convênio de Pós-Graduac¸ão – PEC-PG, da CAPES/CNPq – Brazil.
Publisher Copyright:
© 2015 Informa UK Ltd. All rights reserved.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Objective: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP). Methods: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014. Results: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality. Conclusion: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.
AB - Objective: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP). Methods: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014. Results: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality. Conclusion: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.
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U2 - 10.3109/17518423.2014.948640
DO - 10.3109/17518423.2014.948640
M3 - Review article
C2 - 25180438
AN - SCOPUS:84920997967
VL - 18
SP - 1
EP - 14
JO - Developmental Neurorehabilitation
JF - Developmental Neurorehabilitation
SN - 1751-8423
IS - 1
ER -