Interrelationship between broadband NIRS measurements of cerebral cytochrome C oxidase and systemic changes indicates injury severity in neonatal encephalopathy

Gemma Bale, Subhabrata Mitra, Isabel de Roever, Marcus Chan, Alexander Caicedo-Dorado, Judith Meek, Nicola Robertson, Ilias Tachtsidis

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8 Scopus citations


Perinatal hypoxic ischaemic encephalopathy (HIE) is associated with severe neurodevelopmental problems and mortality. There is a clinical need for techniques to provide cotside assessment of the injury extent. This study aims to use non-invasive cerebral broadband near-infrared spectroscopy (NIRS) in combination with systemic physiology to assess the severity of HIE injury. Broadband NIRS is used to measure the changes in haemodynamics, oxygenation and the oxidation state of cytochrome c oxidase (oxCCO). We used canonical correlation analysis (CCA), a multivariate statistical technique, to measure the relationship between cerebral broadband NIRS measurements and systemic physiology. A strong relationship between the metabolic marker, oxCCO, and systemic changes indicated severe brain injury; if more than 60 % of the oxCCO signal could be explained by the systemic variations, then the neurodevelopmental outcome was poor. This boundary has high sensitivity and specifi city (100 and 83 %, respectively). Broadband NIRS measured concentration changes of the oxidation state of cytochrome c oxidase has the potential to become a useful cotside tool for assessment of injury severity following hypoxic ischaemic brain injury.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalAdvances in Experimental Medicine and Biology
StatePublished - 2016
Externally publishedYes
Event43rd Annual Meeting of the International Society on Oxygen Transport to Tissue, ISOTT 2015 - Wuhan, China
Duration: Jul 11 2015Jul 16 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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