Conidia of P. brasiliensis ingested by murine macrophages at 37°C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells.
|Original language||English (US)|
|Number of pages||3|
|Journal||Infection and Immunity|
|State||Published - 1994|
All Science Journal Classification (ASJC) codes
- Infectious Diseases