Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: Reversal by holotransferrin

L. E. Cano, B. Gomez, E. Brummer, A. Restrepo, D. A. Stevens

Research output: Contribution to journalComment/debatepeer-review

30 Scopus citations

Abstract

Conidia of P. brasiliensis ingested by murine macrophages at 37°C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells.

Original languageEnglish (US)
Pages (from-to)1494-1496
Number of pages3
JournalInfection and Immunity
Volume62
Issue number4
StatePublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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